Zebrafish models of diabetes-related CNS pathogenesis

Anton M Lakstygal; Murilo S de Abreu; Dmitry A Lifanov; Edina A Wappler-Guzzetta; Nazar Serikuly; Erik T Alpsyshov; DongMei Wang; MengYao Wang; ZhiChong Tang; DongNi Yan; Konstantin A Demin; Andrey D Volgin; Tamara G Amstislavskaya; JiaJia Wang; Cai Song; Polina Alekseeva; Allan V Kalueff

doi:10.1016/j.pnpbp.2018.11.016

Zebrafish models of diabetes-related CNS pathogenesis

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8:92:48-58. doi: 10.1016/j.pnpbp.2018.11.016. Epub 2018 Nov 23.

Authors

Anton M Lakstygal¹, Murilo S de Abreu², Dmitry A Lifanov³, Edina A Wappler-Guzzetta⁴, Nazar Serikuly⁵, Erik T Alpsyshov⁵, DongMei Wang⁵, MengYao Wang⁵, ZhiChong Tang⁵, DongNi Yan⁵, Konstantin A Demin⁶, Andrey D Volgin⁷, Tamara G Amstislavskaya⁷, JiaJia Wang⁸, Cai Song⁸, Polina Alekseeva⁹, Allan V Kalueff¹⁰

Affiliations

¹ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.
² Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
³ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; School of Pharmacy, Southwest University, Chongqing, China.
⁴ The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
⁵ School of Pharmacy, Southwest University, Chongqing, China.
⁶ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁷ Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
⁸ Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China.
⁹ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
¹⁰ School of Pharmacy, Southwest University, Chongqing, China; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; ZENEREI Research Center, Slidell, LA, USA. Electronic address: avkalueff@gmail.com.

PMID: 30476525
DOI: 10.1016/j.pnpbp.2018.11.016

Abstract

Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.

Keywords: Behavior; CNS; Diabetes; Glucose; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Behavior, Animal / physiology
Brain / physiopathology
Central Nervous System Diseases* / drug therapy
Central Nervous System Diseases* / genetics
Central Nervous System Diseases* / physiopathology
Diabetes Mellitus* / drug therapy
Diabetes Mellitus* / genetics
Diabetes Mellitus* / physiopathology
Disease Models, Animal*
Humans
Zebrafish*