Abstract
Liquid biopsy is a promising approach to molecular tumor testing in the context of targeted therapy. During this pilot study we applied a high-sensitivity protocol for detection of tumor-derived mutations in circulating plasma DNA of EGFR-positive non-small cell lung cancer (NSCLC) patients during EGFR-TKI therapy. We showed that this protocol was well suited for dynamic monitoring during targeted therapy as well as for detection of acquired resistance mutations.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Carcinoma, Non-Small-Cell Lung / blood
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Carcinoma, Non-Small-Cell Lung / drug therapy*
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Non-Small-Cell Lung / pathology
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Circulating Tumor DNA / blood
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Circulating Tumor DNA / genetics
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Drug Resistance, Neoplasm / genetics*
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ErbB Receptors / blood
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ErbB Receptors / genetics
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Female
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Humans
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Male
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Middle Aged
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Molecular Targeted Therapy
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Mutation
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Pilot Projects
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Protein Kinase Inhibitors / administration & dosage*
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Protein Kinase Inhibitors / adverse effects
Substances
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Circulating Tumor DNA
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Protein Kinase Inhibitors
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EGFR protein, human
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ErbB Receptors