Mint Flavorings from Candies Inhibit the Infectivity of Chlamydia pneumoniae

Nat Prod Commun. 2016 Nov;11(11):1725-1728.

Abstract

The impact of solvent extracts from the distillation water (flavoring extracts) isolated from mint flavored candies on the infectivity of the intracellular bacterium Chlamydia pneumoniae was evaluated by an in vitro model of epithelial cell infections., The mint flavoring extracts were isolated from the candies by simultaneous hydrodistillation and their chemical composition, established by GC-MS, demonstrated menthol and limonene as the most abundant components. Results obtained by treating C. pneumoniae elementary bodies (EBs) with the flavoring extracts or pure reference compounds showed a significant decrease in EB infectivity, achieved with most of the extracts. This antichlamydial activity could be related to the relatively high menthol content of the extracts. Overall, the obtained data indicates that the flavorings present in the candies are able to target the metabolically quiet, non-replicating form of the bacterium and to suppress the spread of this respiratory pathogen from one cell to another.

MeSH terms

  • Candy / analysis*
  • Cell Line
  • Cell Survival / drug effects
  • Chlamydophila pneumoniae / drug effects*
  • Epithelial Cells / drug effects
  • Flavoring Agents / chemistry
  • Flavoring Agents / pharmacology*
  • Humans
  • Mentha / chemistry*

Substances

  • Flavoring Agents