IP-10 is highly involved in HIV infection

Jie Lei; Xiaowan Yin; Hong Shang; Yongjun Jiang

doi:10.1016/j.cyto.2018.11.018

IP-10 is highly involved in HIV infection

Cytokine. 2019 Mar:115:97-103. doi: 10.1016/j.cyto.2018.11.018. Epub 2018 Nov 22.

Authors

Jie Lei¹, Xiaowan Yin¹, Hong Shang², Yongjun Jiang³

Affiliations

¹ NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China.
² NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China. Electronic address: hshang@cmu.edu.cn.
³ NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China. Electronic address: jiangyj@cmu1h.com.

PMID: 30472104
DOI: 10.1016/j.cyto.2018.11.018

Abstract

Interferon-γ (IFN-γ)-induced protein 10 (IP-10 or CXCL-10) is a chemokine involved in trafficking immune cells to inflammatory sites. Numerous studies have reported abnormally high plasma IP-10 levels in the context of human immunodeficiency virus (HIV) infection, and IP-10 is considered an important pro-inflammatory factor in the HIV disease process. The data regarding the roles of IP-10 in HIV infection required collation; this review summarizes the biological characteristics of IP-10, the positive association between plasma IP-10 levels and HIV disease progression, the effect of IP-10 on human immune cells, and potential related mechanisms. This review provides important insights into the role of IP-10 in HIV monitoring and treatment.

Keywords: Disease progression; HIV; IP-10 (CXCL-10); Immune cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemokine CXCL10 / metabolism*
HIV Infections / metabolism*
HIV-1 / pathogenicity
Humans
Inflammation / metabolism
Interferon-gamma / metabolism

Substances

CXCL10 protein, human
Chemokine CXCL10
Interferon-gamma