Genitourinary tuberculosis in Taiwan: A 15-year experience at a teaching hospital

J Microbiol Immunol Infect. 2019 Apr;52(2):312-319. doi: 10.1016/j.jmii.2018.10.007. Epub 2018 Nov 9.

Abstract

Background: Genitourinary tuberculosis (GUTB) is rare but fatal if not diagnosed early. The purpose of this study was to investigate the outcomes of GUTB in Taiwan.

Methods: We retrospectively reviewed medical records of 57 patients who were diagnosed as GUTB from January 2002 to December 2016, over a 15-year period. Demographic data and clinical manifestations were recorded for analysis.

Results: There were 37 males and 20 females with a median age of 71 years. Kidney (24.6%) was the most involved organ. Fever (56.1%) was the major presentation. Sixteen (28.1%) patients presented unfavorable outcome. Compared with the favorable outcome group, the unfavorable outcome group had more malignancy (p = 0.013), fever (p = 0.020), anemia (p = 0007), thrombocytopenia (p = 0.003), and hypoalbuminemia (p = 0.015). In a multivariate analysis, fever (odds ratio: 42.716, 95% confidence interval: 1.032-1767.569; p = 0.048) was identified as prognostic factors for unfavorable outcome.

Conclusion: GUTB is often in advanced stages with a high mortality in Taiwan. Establishing a diagnosis is difficult and requires thorough investigation. Fever is associated with unfavorable outcome.

Keywords: Anemia; Genitourinary tract surgery; Genitourinary tuberculosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia / epidemiology
  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use
  • Female
  • Fever / epidemiology
  • Hospitals, Teaching*
  • Humans
  • Hypoalbuminemia / epidemiology
  • Kaplan-Meier Estimate
  • Kidney Diseases / epidemiology
  • Kidney Diseases / microbiology
  • Logistic Models
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mortality
  • Multivariate Analysis
  • Neoplasms / epidemiology
  • Neoplasms / microbiology
  • Odds Ratio
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Taiwan / epidemiology
  • Thrombocytopenia / epidemiology
  • Treatment Outcome
  • Tuberculosis, Urogenital / drug therapy*
  • Tuberculosis, Urogenital / epidemiology*
  • Tuberculosis, Urogenital / pathology*
  • Tuberculosis, Urogenital / physiopathology*
  • Urinary Tract / surgery

Substances

  • Antitubercular Agents