Multi-component synthesis of fluorophores via catalytic generation of alkynoyl intermediates

Thomas J J Müller

doi:10.1016/j.ddtec.2018.06.003

Multi-component synthesis of fluorophores via catalytic generation of alkynoyl intermediates

Drug Discov Today Technol. 2018 Nov:29:19-26. doi: 10.1016/j.ddtec.2018.06.003. Epub 2018 Jul 2.

Author

Thomas J J Müller¹

Affiliation

¹ Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany. Electronic address: ThomasJJMueller@hhu.de.

PMID: 30471669
DOI: 10.1016/j.ddtec.2018.06.003

Abstract

This account summarizes recent developments of aggregation-induced emissive and emission solvatochromic fluorophores by multicomponent reactions. Key intermediates are catalytically generated alkynoyl derivatives that are directly transformed into luminophores in a one-pot fashion. The conciseness in combination with ready access to tailored chromophore libraries makes this synthetic methodological concept superior over classical multistep syntheses.

Publication types

Review

MeSH terms

Alkynes / chemistry*
Catalysis
Chemistry, Pharmaceutical / methods*
Fluorescent Dyes / chemical synthesis*
Small Molecule Libraries / chemical synthesis*

Substances

Alkynes
Fluorescent Dyes
Small Molecule Libraries