Exons of Leukemia Suppressor Genes: Creative Assembly Required

Trends Cancer. 2018 Dec;4(12):796-798. doi: 10.1016/j.trecan.2018.10.005. Epub 2018 Oct 28.

Abstract

Alternative splicing (AS) has many important roles in the pathogenesis of leukemia. Recent papers suggest that one of its key aspects is exclusion of 3'-terminal exons in favor of premature termination using intronic polyadenylation signals. This process generates leukemia suppressor isoforms with truncated C termini and acting in loss-of-function or dominant-negative manners.

Keywords: RNA processing; alternative splicing; cancer; intronic polyadenylation; leukemia; protein diversity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / genetics
  • Exons / genetics*
  • Gene Expression Regulation, Leukemic*
  • Genes, Tumor Suppressor*
  • Humans
  • Leukemia / genetics*
  • Loss of Function Mutation
  • Polyadenylation / genetics
  • Protein Isoforms / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • Protein Isoforms
  • RNA, Messenger