Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction

Haitham Ballo; Miikka Tarkia; Matti Haavisto; Christoffer Stark; Marjatta Strandberg; Tommi Vähäsilta; Virva Saunavaara; Tuula Tolvanen; Mika Teräs; Ville-Veikko Hynninen; Timo Savunen; Anne Roivainen; Juhani Knuuti; Antti Saraste

doi:10.1016/j.ultrasmedbio.2018.10.005

Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction

Ultrasound Med Biol. 2019 Feb;45(2):568-578. doi: 10.1016/j.ultrasmedbio.2018.10.005. Epub 2018 Nov 19.

Affiliations

¹ Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Heart Center, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: haitham.ballo@utu.fi.
² Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
³ Heart Center, Turku University Hospital and University of Turku, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
⁴ Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
⁵ Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Department of Medical Physics, Division of Medical Imaging, Turku University Hospital, Turku PET Centre, Turku University Hospital, Turku, Finland.
⁶ Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland.
⁷ Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
⁸ Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Turku Center for Disease Modeling, University of Turku, Turku, Finland.
⁹ Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Heart Center, Turku University Hospital and University of Turku, Turku, Finland; Institute of Clinical Medicine, University of Turku, Turku, Finland.

PMID: 30467033
DOI: 10.1016/j.ultrasmedbio.2018.10.005

Abstract

We evaluated the relationships between regional myocardial strain measured by speckle tracking echocardiography and viability, fibrosis, hypertrophy and oxygen consumption in the infarcted or remote myocardium in a pig model of chronic myocardial infarction (MI). Thirteen farm pigs with surgical occlusion of the left anterior descending coronary artery and five sham-operated pigs were studied 3 mo post-MI. Computed tomography revealed significant left ventricle remodeling. Reduced radial or circumferential strain identified areas of transmural infarction (area under the curve: 0.82 and 0.79, respectively). In the remote non-infarcted area, radial strain correlated inversely with the amount of fibrosis (r = -0.66, p = 0.04) and myocyte hypertrophy (r = -0.68, p = 0.03). Radial strain rate inversely correlated with myocardial resting oxygen consumption assessed with ¹¹C-labeled acetate positron emission tomography (r = -0.71, p = 0.006). In conclusion, myocardial strain and strain rate reflect fibrosis, hypertrophy and oxygen consumption of the remote areas after MI.

Keywords: Cardiac computed tomography; Myocardial oxygen consumption; Myocardial perfusion; Positron emission tomography; Transthoracic echocardiography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chronic Disease
Disease Models, Animal
Echocardiography / methods*
Heart / diagnostic imaging*
Heart / physiopathology*
Male
Myocardial Infarction / diagnostic imaging*
Myocardial Infarction / physiopathology*
Swine