Connective Tissue Disease: Current Concepts

Dermatol Clin. 2019 Jan;37(1):37-48. doi: 10.1016/j.det.2018.07.006. Epub 2018 Nov 1.

Abstract

Connective tissue diseases often prominently affect the skin, requiring dermatologists to play an important role in diagnosis and treatment of these patients. Herein we describe updates on the pathogenesis, clinical features, and treatment of 4 major connective tissue diseases: dermatomyositis, cutaneous lupus erythematosus, limited scleroderma (morphea), and cutaneous vasculitis. Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists who have expertise in these conditions.

Keywords: Connective tissue disease; Cutaneous lupus erythematosus; Cutaneous vasculitis; Dermatomyositis; Morphea.

Publication types

  • Review

MeSH terms

  • Antimalarials / therapeutic use
  • Biomarkers / blood
  • Dermatomyositis / classification*
  • Dermatomyositis / drug therapy*
  • Humans
  • IgA Vasculitis / diagnosis
  • Lupus Erythematosus, Cutaneous / drug therapy*
  • Lupus Erythematosus, Cutaneous / physiopathology
  • Scleroderma, Localized / blood
  • Scleroderma, Localized / classification
  • Scleroderma, Localized / therapy*
  • Skin Diseases, Vascular / classification
  • Skin Diseases, Vascular / diagnosis
  • Skin Diseases, Vascular / drug therapy
  • Vasculitis / classification
  • Vasculitis / diagnosis
  • Vasculitis / drug therapy

Substances

  • Antimalarials
  • Biomarkers