Skeletal Manifestations of Hypoparathyroidism

Bone. 2019 Mar:120:548-555. doi: 10.1016/j.bone.2018.11.012. Epub 2018 Nov 19.

Abstract

Chronic PTH deficiency has a marked effect on the skeleton, leading to characteristic decreases in bone remodeling and increases in bone mass. An effect on fracture risk has not been demonstrated, although biochemical, imaging, and histomorphometric data indicate abnormalities in skeletal properties1,21,21,21,2. Replacement with PTH leads to a new skeletal state that is maintained with long-term treatment.

Keywords: Bone; Histomorphometry; Hypoparathyroidism; Imaging; rhPTH(1–84).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Density / drug effects
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / pathology*
  • Fractures, Bone / etiology
  • Humans
  • Hypoparathyroidism / diagnostic imaging
  • Hypoparathyroidism / drug therapy
  • Hypoparathyroidism / pathology*
  • Parathyroid Hormone / pharmacology
  • Parathyroid Hormone / therapeutic use
  • Risk Factors

Substances

  • Parathyroid Hormone