Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity

Chem Commun (Camb). 2018 Dec 18;55(1):27-30. doi: 10.1039/c8cc08413k.

Abstract

An activatable organic semiconducting nanoprobe that specifically turns on its second near-infrared window fluorescence upon being exposed to nitric oxide stimuli was developed for in vivo, in situ, real-time and high-spatial-resolution mapping of drug-induced hepatotoxicity.

MeSH terms

  • Acetaminophen / toxicity*
  • Animals
  • Chemical and Drug Induced Liver Injury / diagnostic imaging
  • Chemical and Drug Induced Liver Injury / etiology
  • Fluorescent Dyes / chemistry*
  • Hep G2 Cells
  • Humans
  • Maleates / chemistry
  • Mice
  • Nanostructures / chemistry*
  • Nitric Oxide / chemistry
  • Nitric Oxide / metabolism
  • Oxidation-Reduction
  • Polystyrenes / chemistry
  • Semiconductors*
  • Spectroscopy, Near-Infrared
  • Triazoles / chemistry

Substances

  • Fluorescent Dyes
  • Maleates
  • Polystyrenes
  • Triazoles
  • poly(styrene-co-maleic anhydride)
  • Nitric Oxide
  • Acetaminophen
  • benzotriazole