The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period

Biol Trace Elem Res. 2019 Aug;190(2):517-525. doi: 10.1007/s12011-018-1580-y. Epub 2018 Nov 21.

Abstract

This paper focuses on negative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on element content in male chicken calvaria and α-tocopherol (vitamin E) ability to reduce its toxic potential on bone mineralization in offspring. In the experiment carried out once, a solution containing only DMSO, TCDD, TCDD + α-tocopherol, and exclusively α-tocopherol was administrated. Subsequently, on the 5th day after hatching, the mineral composition of the chicken calvaria was evaluated. The results obtained suggest that the use of α-tocopherol contributes to the maintenance of the concentration of calcium, magnesium, and manganese in the chicken calvaria treated with TCDD in the embryonic period. In turn, vitamin E increases the level of zinc. It has been found that α-tocopherol in chicken embryos has a protective effect against disturbance of level of chosen trace elements in the bones of offspring caused by the TCDD.

Keywords: Calvaria; Chicken; Dioxin; Mineral component; Toxicity; Vitamin E.

MeSH terms

  • Animals
  • Calcium / analysis
  • Chick Embryo
  • Chickens
  • Magnesium / analysis
  • Male
  • Polychlorinated Dibenzodioxins / toxicity*
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Skull / chemistry
  • Skull / drug effects*
  • Trace Elements / analysis*
  • Vitamin E / administration & dosage
  • Vitamin E / pharmacology
  • alpha-Tocopherol / administration & dosage
  • alpha-Tocopherol / pharmacology*

Substances

  • Polychlorinated Dibenzodioxins
  • Protective Agents
  • Trace Elements
  • Vitamin E
  • alpha-Tocopherol
  • Magnesium
  • Calcium