Diazachlorin and diazabacteriochlorin for one- and two-photon photodynamic therapy

Jean-François Longevial; Ayaka Yamaji; Dina Aggad; Gakhyun Kim; Wen Xi Chia; Tsubasa Nishimura; Yoshihiro Miyake; Sébastien Clément; Juwon Oh; Morgane Daurat; Christophe Nguyen; Dongho Kim; Magali Gary-Bobo; Sébastien Richeter; Hiroshi Shinokubo

doi:10.1039/c8cc07489e

Diazachlorin and diazabacteriochlorin for one- and two-photon photodynamic therapy

Chem Commun (Camb). 2018 Dec 6;54(98):13829-13832. doi: 10.1039/c8cc07489e.

Authors

Jean-François Longevial¹, Ayaka Yamaji, Dina Aggad, Gakhyun Kim, Wen Xi Chia, Tsubasa Nishimura, Yoshihiro Miyake, Sébastien Clément, Juwon Oh, Morgane Daurat, Christophe Nguyen, Dongho Kim, Magali Gary-Bobo, Sébastien Richeter, Hiroshi Shinokubo

Affiliation

¹ Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan. hshino@chembio.nagoya-u.ac.jp.

PMID: 30462101
DOI: 10.1039/c8cc07489e

Abstract

Diazachlorin and diazabacteriochlorin have been prepared through reduction of diazaporphyrin and their in vitro and in vivo activity in photodynamic therapy has been investigated.

MeSH terms

Animals
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology
Cell Line, Tumor
Female
Humans
MCF-7 Cells
Models, Molecular
Photochemotherapy* / methods
Photons
Photosensitizing Agents / chemical synthesis
Photosensitizing Agents / chemistry*
Photosensitizing Agents / therapeutic use*
Zebrafish

Substances

Photosensitizing Agents