Catalytic C1 Alkylation with Methanol and Isotope-Labeled Methanol

Abstract

A metal-catalyzed methylation process has been developed. By employing an air- and moisture-stable manganese catalyst together with isotopically labeled methanol, a series of D-, CD₃ -, and ¹³ C-labeled products were obtained in good yields under mild reaction conditions with water as the only byproduct.

Keywords: alkylation; manganese; methylation; transition-metal catalysis; trideuteromethylation.