Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

Nima Hemmat; Hossein Bannazadeh Baghi

doi:10.1186/s13027-018-0208-3

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

Infect Agent Cancer. 2018 Nov 9:13:31. doi: 10.1186/s13027-018-0208-3. eCollection 2018.

Authors

Nima Hemmat^{1

2}, Hossein Bannazadeh Baghi^{1

3

4}

Affiliations

¹ 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² 2Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
³ 3Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran.
⁴ 4Department of Microbiology Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play important roles in cancer progression and maintenance. However, the high risk HPV E5 protein is also demonstrated to affect some cellular pathway and signaling in human cell lines. In this letter we argue for the need of further investigation and suggest that the HPV E5 protein should be acknowledged as an oncoprotein of HPV.

Keywords: Cervical cancer; HPV; HPV E5 protein; Tumorigenesis.