Building Biological Shields via Hormesis

Edward J Calabrese; Evgenios Agathokleous

doi:10.1016/j.tips.2018.10.010

Building Biological Shields via Hormesis

Trends Pharmacol Sci. 2019 Jan;40(1):8-10. doi: 10.1016/j.tips.2018.10.010. Epub 2018 Nov 16.

Authors

Edward J Calabrese¹, Evgenios Agathokleous²

Affiliations

¹ Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: edwardc@schoolph.umass.edu.
² Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido, 062-8516, Japan; Research Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo, Hokkaido, 060-8589, Japan.

PMID: 30455065
DOI: 10.1016/j.tips.2018.10.010

Abstract

Hormesis offers the potential to build biological shields to protect against a plethora of age-related diseases and acute trauma (e.g., brain traumatic injury) via the implementation of pre- and postconditioning strategies. These strategies have the potential to markedly enhance a broad spectrum of medical and public health practices.

Keywords: adaptive response; dose response; hormesis; postconditioning; preconditioning; public health.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Acute Disease
Aging / physiology*
Animals
Brain Injuries, Traumatic / physiopathology
Brain Injuries, Traumatic / prevention & control
Hormesis / physiology*
Humans
Public Health
Wounds and Injuries / physiopathology
Wounds and Injuries / prevention & control*