Tubulointerstitial Nephritis

Rebecca L Ruebner; Jeffrey J Fadrowski

doi:10.1016/j.pcl.2018.08.009

Tubulointerstitial Nephritis

Pediatr Clin North Am. 2019 Feb;66(1):111-119. doi: 10.1016/j.pcl.2018.08.009.

Authors

Rebecca L Ruebner¹, Jeffrey J Fadrowski²

Affiliations

¹ Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA. Electronic address: Rruebne1@jhmi.edu.
² Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA.

PMID: 30454737
DOI: 10.1016/j.pcl.2018.08.009

Abstract

Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicated for severe or prolonged disease.

Keywords: Acute interstitial nephritis; Acute kidney injury; Tubulointerstitial nephritis; Tubulointerstitial nephritis with uveitis.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use*
Child
Diagnosis, Differential
Humans
Immunosuppressive Agents / therapeutic use*
Nephritis, Interstitial / diagnosis*
Nephritis, Interstitial / drug therapy*
Nephritis, Interstitial / etiology

Substances

Adrenal Cortex Hormones
Immunosuppressive Agents