Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has involved in many researches and it has been confirmed that the expression of Ang-2 is significantly up-regulated in tissues and blood of NSCLC. Meanwhile, Ang-2 is related to malignant biological behavior of cancer cells, making it a potential biological marker for the diagnosis and prognosis of NSCLC. At present, researches on Ang-2 how to promote the progression of NSCLC around the world are focused on Ang-2 regulating the proliferation, invasion, and metastasis of NSCLC. This paper summarized and estimated the studies and literature reports of regulatory mechanisms of Ang-2 in NSCLC, hopefully it could help looking for targeted drug treatment of Ang-2 in the future. .
【中文题目：非小细胞肺癌中Ang-2相关研究进展】 【中文摘要：非小细胞肺癌（non-small cell lung cancer, NSCLC）是全世界病死率最高的恶性肿瘤之一，也是临床上棘手的难题，其发生发展与肿瘤新生血管的形成密不可分。血管生成素-2（angiopoietin-2, Ang-2）是目前研究较为深入且重要的促血管生成因子，已被证实在NSCLC组织、血液中表达显著上调，并与癌细胞恶性生物学行为呈正相关，有望成为NSCLC诊断和预后的潜在生物学标志物。目前国内外对于Ang-2是如何参与NSCLC进展的相关研究主要集中于增殖、侵袭、转移等方面。本文对近年来NSCLC中涉及Ang-2调控机制的各项研究和文献报道进行总结与评价，期望对未来针对Ang-2的靶向药物研究有所启发。 】 【中文关键词：肺肿瘤；血管生成素-2；新生血管；侵袭与转移】.
Keywords: Angiogenesis; Angiopoietin-2; Invasion and metastasis; Lung neoplasms.