Phytochemical investigation of the fruiting body of Volvariella volvacea led to the isolation of a new furanone, 2(5H)-furanone-4-propionic acid named volvafuranone A (1), together with twelve known compounds (2-13). Compounds 2-7, 9-11 were isolated from this mushroom for the first time. The isolated compounds were assessed for their cytotoxicity against four human tumour lines (SGC-7901, PC-3M, MCF-7, HepG-2), and the results showed that compound 2, 3, 12, 13 have significant cytotoxicity with IC50 values of 5.90 μM (HepG-2), 20.72 μM (HepG-2), 27.98 μM (PC-3M) and 23.15 μM (PC-3M), respectively.
Keywords: 2 (5H)-furanone-4- propionic acid; Volvariella volvacea; cytotoxicity; furanone; volvafuranone A.