Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window

Zuwu Wei; Ming Wu; Shanyou Lan; Jiong Li; Xiaolong Zhang; Da Zhang; Xiaolong Liu; Jingfeng Liu

doi:10.1039/c8cc07583b

Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window

Chem Commun (Camb). 2018 Dec 14;54(96):13599-13602. doi: 10.1039/c8cc07583b. Epub 2018 Nov 19.

Authors

Zuwu Wei¹, Ming Wu¹, Shanyou Lan², Jiong Li³, Xiaolong Zhang¹, Da Zhang¹, Xiaolong Liu⁴, Jingfeng Liu⁵

Affiliations

¹ The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China.
² The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China.
³ The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.
⁴ The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.
⁵ The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.

PMID: 30451251
DOI: 10.1039/c8cc07583b

Abstract

We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability. Furthermore, our nanoparticles could be efficiently uptaken by cancer cells and exhibited outstanding anticancer ability both in vitro and in vivo under NIR-II laser irradiation.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / radiation effects
Antineoplastic Agents / therapeutic use*
Antineoplastic Agents / toxicity
Apoptosis / drug effects
Cell Survival / drug effects
Female
HeLa Cells
Heating
Humans
Infrared Rays
Mice, Inbred BALB C
Mice, Nude
Nanoparticles / chemistry*
Nanoparticles / radiation effects
Phototherapy / methods
Polymers / chemical synthesis
Polymers / radiation effects
Polymers / therapeutic use*
Polymers / toxicity
Pyrroles / chemical synthesis
Pyrroles / radiation effects
Pyrroles / therapeutic use*
Pyrroles / toxicity
Uterine Cervical Neoplasms / therapy*

Substances

Antineoplastic Agents
Polymers
Pyrroles