An explanation for the narrow carbohydrate substrate specificity of adenine phosphoribosyltransferase from Thermus thermophilus from the model of the enzyme, substrate, and magnesium cation cofactor complex

J Biomol Struct Dyn. 2019 Oct;37(17):4460-4464. doi: 10.1080/07391102.2018.1550020. Epub 2018 Dec 31.

Abstract

Communicated by Ramaswamy H. Sarma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine Phosphoribosyltransferase / metabolism*
  • Binding Sites
  • Biocatalysis
  • Carbohydrates / chemistry*
  • Cations
  • Coenzymes / metabolism*
  • Magnesium / metabolism*
  • Models, Molecular
  • Protein Conformation
  • Substrate Specificity
  • Thermus thermophilus / enzymology*

Substances

  • Carbohydrates
  • Cations
  • Coenzymes
  • Adenine Phosphoribosyltransferase
  • Magnesium