A Scalable Optoelectronic Neural Probe Architecture With Self-Diagnostic Capability

IEEE Trans Circuits Syst I Regul Pap. 2018 Jan 24;65(8):2431-2442. doi: 10.1109/TCSI.2018.2792219. eCollection 2018 Aug.

Abstract

There is a growing demand for the development of new types of implantable optoelectronics to support both basic neuroscience and optogenetic treatments for neurological disorders. Target specification requirements include multi-site optical stimulation, programmable radiance profile, safe operation, and miniaturization. It is also preferable to have a simple serial interface rather than large numbers of control lines. This paper demonstrates an optrode structure comprising of a standard complementary metal-oxide-semiconductor process with 18 optical stimulation drivers. Furthermore, diagnostic sensing circuitry is incorporated to determine the long-term functionality of the photonic elements. A digital control system is incorporated to allow independent multisite control and serial communication with external control units.

Keywords: Active optrode; implantable; neural stimulation; optogenetics; self-diagnostic.

Grants and funding

This work was supported in part by the European Commission OptoNeuro FP7 Program under Grant 249867 and the Wellcome Trust-EPSRC through the CANDO Project under Grant NS/A000026/1. The work of H. Zhao was supported in part by the Newcastle University Doctoral Scholarship and the GBCET-SC Scholarships.