Rare dimeric guaianes from Xylopia vielana and their multidrug resistance reversal activity

Phytochemistry. 2019 Feb:158:26-34. doi: 10.1016/j.phytochem.2018.11.004. Epub 2018 Nov 15.

Abstract

Thirteen undescribed dimeric guaianes were isolated from the leaves of Xylopia vielana Pierre. Their structures were elucidated by NMR spectroscopy and mass spectrometry, and the absolute configurations of vielanins G-Q were determined by a combination of the circular dichroism (CD) exciton chirality method, chemical conversion, and electronic CD (ECD) spectroscopy analysis. Vielaninors A and B are the first examples of trinor-guaiane-dimers. Multidrug resistance reversal activity assay of the isolates was evaluated in doxorubicin-resistant human breast cancer cells. Vielanins H, K-M, P, and Q were noncytotoxic and enhanced the cytotoxicity of doxorubicin by 2.1-41.6-fold at 10 μM.

Keywords: Annonaceae; Guaiane; Sesquiterpenoid dimers; Xylopia vielana Pierre.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Circular Dichroism
  • Dimerization
  • Doxorubicin / pharmacology
  • Drug Resistance, Multiple / drug effects
  • Drug Resistance, Neoplasm / drug effects*
  • Drug Screening Assays, Antitumor / methods
  • Female
  • Humans
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Sesquiterpenes, Guaiane / chemistry
  • Sesquiterpenes, Guaiane / pharmacology*
  • Xylopia / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes, Guaiane
  • guaiane
  • Doxorubicin