Expression and functional analysis of flotillins in Dugesia japonica

Exp Cell Res. 2019 Jan 1;374(1):76-84. doi: 10.1016/j.yexcr.2018.11.009. Epub 2018 Nov 15.

Abstract

FLOTILLIN-1 and FLOTILLIN-2 are membrane rafts associated proteins that have been implicated in insulin and growth factor signaling, endocytosis, cell migration, proliferation, differentiation, cytoskeleton remodeling and membrane trafficking. Furthermore, FLOTILLINs also play important roles in the progression of cancer and neurodegenerative diseases. In this study, the roles of flotillins are investigated in planarian Dugesia japonica. The results show that Djflotillin-1 and Djflotillin-2 play a key role in homeostasis maintenance and regeneration process by regulating the proliferation of the neoblast cells, they are not involved in the maintenance and regeneration of the central nervous system in planarians.

Keywords: Djflotillins; Planarian; Proliferation; Regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System / metabolism
  • Gene Expression Regulation
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Phenotype
  • Planarians / genetics
  • Planarians / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Regeneration
  • Sequence Homology, Amino Acid
  • Time Factors

Substances

  • Membrane Proteins
  • RNA, Messenger
  • flotillins