Emerging role of circadian rhythm in bone remodeling

J Mol Med (Berl). 2019 Jan;97(1):19-24. doi: 10.1007/s00109-018-1723-9. Epub 2018 Nov 16.

Abstract

The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metabolic diseases. In recent decades, increased understanding of the roles of circadian rhythm genes in the bone remodeling process have been documented, including osteoblastic bone formation, osteoclastic bone resorption, and osteoblast/osteoclast communication. A timely review of the current findings may help to facilitate the new field of circadian rhythmic bone remodeling research. Targeted pharmacological modulation of circadian rhythm genes is a possible therapeutic approach through which to overcome bone remodeling problems in the future.

Keywords: Bone remodeling; Circadian rhythm; Osteoblast; Osteoclast.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Remodeling*
  • Circadian Clocks
  • Circadian Rhythm*
  • Humans
  • Osteoblasts / cytology
  • Osteoblasts / metabolism
  • Osteoclasts / cytology
  • Osteoclasts / metabolism