Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl

Nat Prod Res. 2019 Oct;33(20):2904-2910. doi: 10.1080/14786419.2018.1509336. Epub 2018 Nov 16.

Abstract

Three new labdane-type diterpenoids, callicapene M3-M5 (1-3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1-3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72 μM respectively.

Keywords: Callicarpa macrophylla Vahl.; NO inhibition; labdane-type diterpenoids.

MeSH terms

  • Animals
  • Callicarpa / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Inhibitory Concentration 50
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Plant Leaves / chemistry
  • RAW 264.7 Cells

Substances

  • Diterpenes
  • labdane
  • Nitric Oxide