Abstract
Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in detail based on its 2D-NMR data. Compound 1 showed weak cytotoxicity against the cell lines of T-24, NCI-H460, HepG2, SMMC-7721, CNE, MDA-MB-231 and B16F10 with the inhibition rates from 10.01% to 34.05% at the concentration of 80 μM.
Keywords:
Melia azedarach L.; benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate; cytotoxicity.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Hep G2 Cells
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Humans
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Kaempferols / chemistry
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Kaempferols / isolation & purification
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Kaempferols / pharmacology
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Magnetic Resonance Spectroscopy
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Melia azedarach / chemistry*
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Molecular Structure
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Plant Leaves / chemistry*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Glucosides
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Kaempferols
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Sesquiterpenes
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spathulenol
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Quercetin
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astragalin