Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis

Cristian Caimmi; Eugenia Bertoldo; Anna Venturini; Paola Caramaschi; Luca Frulloni; Rachele Ciccocioppo; Sabrina Brunelli; Luca Idolazzi; Davide Gatti; Maurizio Rossini; Ombretta Viapiana

doi:10.3899/jrheum.171445

Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis

J Rheumatol. 2019 Mar;46(3):274-278. doi: 10.3899/jrheum.171445. Epub 2018 Nov 15.

Authors

Cristian Caimmi^{1

2}, Eugenia Bertoldo^{3

4}, Anna Venturini^{3

4}, Paola Caramaschi^{3

4}, Luca Frulloni^{3

4}, Rachele Ciccocioppo^{3

4}, Sabrina Brunelli^{3

4}, Luca Idolazzi^{3

4}, Davide Gatti^{3

4}, Maurizio Rossini^{3

4}, Ombretta Viapiana^{3

4}

Affiliations

¹ From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. cristian.caimmi@gmail.com.
² C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. cristian.caimmi@gmail.com.
³ From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy.
⁴ C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi.

PMID: 30442820
DOI: 10.3899/jrheum.171445

Abstract

Objective: To evaluate the relationship between fecal calprotectin (FC) and interstitial lung disease (ILD) in systemic sclerosis (SSc).

Methods: The study enrolled 129 outpatients with SSc. Data about disease characteristics, in particular lung involvement, were collected and FC was measured.

Results: Patients with ILD (35, 27.1%) had higher values of FC (p < 0.001). In multivariate analysis, these variables were associated with increased risk of ILD: diffuse disease subset, higher modified Rodnan skin score, longer disease duration, higher severity scores, steroid treatment, and higher FC levels, while diverticulosis was protective.

Conclusion: ILD is independently associated with increased FC levels in SSc.

Keywords: FECAL CALPROTECTIN; INTERSTITIAL LUNG DISEASE; SYSTEMIC SCLEROSIS.

Publication types

Observational Study

MeSH terms

Aged
Cohort Studies
Dysbiosis / complications
Feces / chemistry*
Female
Gastrointestinal Microbiome
Humans
Leukocyte L1 Antigen Complex / analysis*
Lung Diseases, Interstitial / diagnosis*
Lung Diseases, Interstitial / etiology*
Male
Middle Aged
Respiratory Function Tests
Risk Factors
Scleroderma, Systemic / complications*
Severity of Illness Index
Tomography Scanners, X-Ray Computed

Substances

Leukocyte L1 Antigen Complex