Objective: To investigate the changes of brain gray matter volume in patients with occupational noise-induced hearing loss by voxel based morphometry (VBM) . Methods: 16 age-and education-matched healthy controls and 42 patients with occupational noise induced hearing loss, including 27 in mild group and 15 in severe group, received MRI 3D-FSPGR sequence T1WI sagittal scan, and then underwent VBM of brain gray matter volume data analysis. Results: The brain gray matter volume of the left occipitotemporal lateral gyrus, the anterior cingulate gyrus, the bilateral angular gyrus, the precuneus and the near midline area of cerebellum differed between experimental group and control group (P<0.01) . Conclusion: The volume of gray matter in specific brain areas of patients with occupational noise-induced hearing loss was changed, and the effect of noise on brain structure was revealed from the perspective of imaging.
目的： 应用MRI基于体素的形态学测量（VBM）方法研究职业性噪声聋患者脑灰质的变化。 方法： 42例职业性噪声聋患者，其中轻度组27名，中重度组15名及年龄、教育水平匹配的健康对照组16名均接受MRI全脑3D-FSPGR序列T1WI矢状位扫描，并进行VBM脑灰质数据分析。 结果： 噪声聋患者与对照组的左枕颞外侧回、扣带回前部、双侧角回、楔前叶及小脑近中线区域脑灰质容积差异有统计学意义（P<0.01）。 结论： 职业性噪声聋患者的特定脑区灰质容积发生了改变，从影像学角度揭示噪声对脑功能结构的影响。.
Keywords: Occupational Noise-induced Hearing Loss; Voxel.