A new antimicrobial sesquiterpene isolated from endophytic fungus Cytospora sp. from the Chinese mangrove plant Ceriops tagal

Nat Prod Res. 2020 May;34(10):1404-1408. doi: 10.1080/14786419.2018.1512993. Epub 2018 Nov 10.

Abstract

Chemical examination of Chinese mangrove Ceriops tagal endophytic Cytospora sp., yielded a new biscyclic sesquiterpene seiricardine D (1), and eight known metabolites, xylariterpenoid A (2a), xylariterpenoid B (2b) and regiolone (3) 4-hydroxyphenethyl alcohol (4), (22E, 24R)5, 8-epidioxy-5α, 8α-ergosta-6,22E-dien-3ß-ol (5), (22E, 24R)5, 8-epidioxy-5α, 8α-ergosta-6,9(11), 22-trien-3 ß-ol (6), ß-sitosterol (7) and stigmast-4-en-3-one (8). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. The antimicrobial activities of compounds 1-8 and their effects on a panel of plant and human pathogens were evaluated.

Keywords: Ceriops tagal; Cytospora sp.; antimicrobial activity; seiricardine D.

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Ascomycota / chemistry*
  • Humans
  • Molecular Structure
  • Rhizophoraceae / microbiology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sitosterols / isolation & purification
  • Spectrum Analysis / methods
  • Stigmasterol / analogs & derivatives
  • Stigmasterol / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Sesquiterpenes
  • Sitosterols
  • stigmast-4-en-3-one
  • gamma-sitosterol
  • Stigmasterol