Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform

F1000Res. 2018 Jan 17:7:75. doi: 10.12688/f1000research.13197.2. eCollection 2018.

Abstract

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.

Keywords: API; Open PHACTS; WikiPathways; bioinformatics; drug discovery; pathway database; semantic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Biomedical Research*
  • Computational Biology / methods*
  • Drug Discovery*
  • Drug Industry
  • Humans
  • Hypertrophy / drug therapy
  • Hypertrophy / pathology
  • Information Storage and Retrieval / methods*
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / drug effects
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Signal Transduction*
  • Software*

Substances

  • Antineoplastic Agents

Grants and funding

This work was supported by the Innovative Medicines Initiative Joint Undertaking [115191], resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution.