Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults

Jingsi Chen; Xiaofeng Zhou; Han Zhang; Yueming Liu; Chen Cao; Ruihua Dong; Yaqun Yuan; Min Wang; Yuanan Lu; Min Wu; Shuguang Li; Bo Chen

doi:10.1016/j.envpol.2018.10.044

Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults

Environ Pollut. 2019 Feb:245:149-162. doi: 10.1016/j.envpol.2018.10.044. Epub 2018 Nov 2.

Authors

Jingsi Chen¹, Xiaofeng Zhou², Han Zhang³, Yueming Liu⁴, Chen Cao⁵, Ruihua Dong⁶, Yaqun Yuan⁷, Min Wang⁸, Yuanan Lu⁹, Min Wu¹⁰, Shuguang Li¹¹, Bo Chen¹²

Affiliations

¹ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: 15211020022@fudan.edu.cn.
² Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: 17211020021@fudan.edu.cn.
³ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: 13211020025@fudan.edu.cn.
⁴ Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China. Electronic address: liuym@shciq.gov.cn.
⁵ Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China. Electronic address: caoc@shciq.gov.cn.
⁶ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: 15111020019@fudan.edu.cn.
⁷ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: yqyuan16@fudan.edu.cn.
⁸ Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China. Electronic address: wangm@shciq.gov.cn.
⁹ Environmental Health Laboratory, Department of Public Health, University of Hawaii at Manoa, Honolulu, USA. Electronic address: yuanan@hawaii.edu.
¹⁰ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: wumin@shmu.edu.cn.
¹¹ Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: leeshuguang@fudan.edu.cn.
¹² Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China. Electronic address: chenb@fudan.edu.cn.

PMID: 30415034
DOI: 10.1016/j.envpol.2018.10.044

Abstract

Background: Exposure to phthalates is reported to be associated with increased incidence of microalbuminuria and low-grade albuminuria in children and adolescents. However, this phenomenon of phthalate-related nephrotoxicity is unknown in adults.

Methods: Urine samples of 1663 adults from the 2012 Shanghai Food Consumption Survey (SHFCS) were measured for 10 metabolites of 6 phthalates and for renal function parameters. Their associations were explored by linear and logistic regression models.

Results: Multivariate linear regression analysis showed that all three renal function parameters (albumin-to-creatinine ratio (ACR), β2-microglobulin (B2M), and N-acetyl-β-d-glucosaminidase (NAG)) are positively associated with six metabolites, including mono-benzylphthalate (MBzP), mono-2-ethylhexylphthalate (MEHP), mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate (MEHHP), mono-2-ethyl-5-carboxypentylphthalate (MECPP), and mono-2-carboxymethyl-hexyl phthalate (MCMHP) (P < 0.05). Logistic analysis showed that the prevalence of hyperALBuria, hyperB2Muria, hyperNAGuria, or potentially impaired renal function (PIRF) were positively associated with urinary levels of MBzP, MEOHP, and MECPP, respectively (P < 0.05). Co-exposure to identified risk metabolites monoethylphthalate (MEP), MBzP, MEHP, MEOHP, MECPP, MEHHP, and MCMHP increased the risk of having impaired renal function.

Conclusion: Certain metabolites of phthalates, including bis (2-ethylhexyl) phthalate (DEHP) and benzyle butyl phthalate (BBzP), were associated with impaired renal function in Shanghai adults.

Keywords: Albumin; Metabolites of phthalates; N-Acetyl-β-d-glucosaminidase; Shanghai adults; β2-microglobulin.

MeSH terms

Adolescent
Adult
Child
China
Environmental Exposure / adverse effects*
Female
Humans
Kidney Diseases / epidemiology*
Kidney Diseases / etiology
Kidney Diseases / urine
Linear Models
Logistic Models
Male
Multivariate Analysis
Phthalic Acids / metabolism
Phthalic Acids / toxicity
Phthalic Acids / urine*

Substances

Phthalic Acids
phthalic acid