Deep brain stimulation targets for treating depression

Dominik Drobisz; Alena Damborská

doi:10.1016/j.bbr.2018.11.004

Deep brain stimulation targets for treating depression

Behav Brain Res. 2019 Feb 1:359:266-273. doi: 10.1016/j.bbr.2018.11.004. Epub 2018 Nov 8.

Authors

Dominik Drobisz¹, Alena Damborská²

Affiliations

¹ Department of Psychiatry, University Hospital and Masaryk University, Brno, Czech Republic.
² Department of Psychiatry, University Hospital and Masaryk University, Brno, Czech Republic; Department of Basic Neurosciences, University of Geneva, Campus Biotech, Geneva, Switzerland; CEITEC - Central European Institute of Technology, Brain and Mind Research Program, Masaryk University, Brno, Czech Republic. Electronic address: Alena.Damborska@unige.ch.

PMID: 30414974
DOI: 10.1016/j.bbr.2018.11.004

Abstract

Deep brain stimulation (DBS) is a new therapeutic approach for treatment-resistant depression (TRD). There is a preliminary evidence of the efficacy and safety of DBS for TRD in the subgenual anterior cingulate cortex, the ventral capsule/ventral striatum, the nucleus accumbens, the lateral habenula, the inferior thalamic peduncle, the medial forebrain bundle, and the bed nucleus of the stria terminalis. Optimal stimulation targets, however, have not yet been determined. Here we provide updated knowledge substantiating the suitability of each of the current and potential future DBS targets for treating depression. In this review, we discuss the future outlook for DBS treatment of depression in light of the fact that antidepressant effects of DBS can be achieved using different targets.

Keywords: Deep brain stimulation; Major depressive disorder; Treatment-resistant depression.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / physiopathology
Deep Brain Stimulation* / methods
Depressive Disorder / physiopathology
Depressive Disorder / therapy*
Humans