Withanolides and aromatic glycosides isolated from Nicandra physaloides and their anti-inflammatory activity

Fitoterapia. 2018 Nov:131:260-264. doi: 10.1016/j.fitote.2018.11.003. Epub 2018 Nov 8.

Abstract

Two new withanolides (1-2) together with five known ones (3-7), and three known aromatic glycosides (8-10) were isolated from the dried stems and leaves of Nicandra physaloides, an edible and medicinal plant. Their structures were identified by extensive spectroscopic analyses or comparison with literature data. The absolute configuration of 2 was assigned via X-ray crystallography. Compound 1 with a spiroketal moiety is relatively unusual in withanolides. Aromatic glycosides (8-10) showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values from 4.69 to 16.12 μM.

Keywords: Aromatic glycosides; NO inhibitory activity; Nicandra physaloides; Withanolides.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • China
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry
  • RAW 264.7 Cells
  • Solanaceae / chemistry*
  • Withanolides / isolation & purification
  • Withanolides / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Glycosides
  • Phytochemicals
  • Withanolides
  • Nitric Oxide