Secondary Haemophagocytic Syndrome and Overlapping Immune Reconstitution Syndrome: Life-Threatening Complications of Anti-TNF-α Treatment for Crohn's Disease

Esteban Sáez-González; Miguel Salavert; Elena Cerrillo; Inés Moret; Marisa Iborra; Pilar Nos; Belén Beltrán

doi:10.1038/s41395-018-0420-1

Secondary Haemophagocytic Syndrome and Overlapping Immune Reconstitution Syndrome: Life-Threatening Complications of Anti-TNF-α Treatment for Crohn's Disease

Am J Gastroenterol. 2019 Jan;114(1):177-179. doi: 10.1038/s41395-018-0420-1.

Authors

Esteban Sáez-González^{1

2}, Miguel Salavert³, Elena Cerrillo^{1

2}, Inés Moret^{1

2

4}, Marisa Iborra^{1

2

4}, Pilar Nos^{1

2

4}, Belén Beltrán^{1

2

4}

Affiliations

¹ Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain.
² Inflammatory Bowel Disease Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain.
³ Infectious Diseases Unit, Department of Internal Medicine, La Fe University and Polytechnic Hospital, Valencia, Spain.
⁴ Networked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD), Madrid, Spain.

PMID: 30413818
DOI: 10.1038/s41395-018-0420-1

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adalimumab / adverse effects*
Adult
Antibodies, Monoclonal / adverse effects*
Crohn Disease / drug therapy*
Diagnosis, Differential
Fever / etiology
Humans
Immune Reconstitution Inflammatory Syndrome / complications
Immune Reconstitution Inflammatory Syndrome / diagnosis*
Lymphohistiocytosis, Hemophagocytic / complications
Lymphohistiocytosis, Hemophagocytic / diagnosis*
Male
Tuberculosis, Pulmonary / complications
Tuberculosis, Pulmonary / diagnosis*
Tumor Necrosis Factor-alpha / immunology

Substances

Antibodies, Monoclonal
Tumor Necrosis Factor-alpha
Adalimumab