Cross design analysis of randomized and observational data - application to continuation rates for a contraceptive intra uterine device containing Levonorgestrel in adolescents and adults

BMC Womens Health. 2018 Nov 9;18(1):180. doi: 10.1186/s12905-018-0674-1.

Abstract

Background: To combine results from a randomized controlled study (RCT) and an observational study (OS) to evaluate discontinuation rate of a levonorgestrel-containing intrauterine contraceptive device (LNG IUD) in a real-life setting.

Methods: We included 253 parous and nulliparous women aged 21-40 years from our own phase II RCT. A total of 1607 women of all ages (including adolescents, < 20 years) were recruited from an OS. We applied the cross design synthesis (CDS) method recommended by the United States General Accounting Office. This method combines the different strengths of RCTs and OSs into one single estimate.

Results: Combined continuation rates for parous vs nulliparous women could be estimated more precisely as well as overall continuation rates after one (86.6%) and two years (78.5%), irrespective of age and parity.

Conclusion: Cross design synthesis allowed more precise estimation of continuation rates of an intrauterine device.

Keywords: Continuation rates; Cross design syntheses; Intra-uterine device.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Contraceptive Agents, Female / therapeutic use*
  • Cross-Sectional Studies*
  • Female
  • Humans
  • Intrauterine Devices, Medicated*
  • Levonorgestrel / therapeutic use*
  • Medication Adherence / statistics & numerical data*
  • Parity*
  • Pregnancy
  • Randomized Controlled Trials as Topic*
  • Young Adult

Substances

  • Contraceptive Agents, Female
  • Levonorgestrel