Phase Synchronization Dynamics of Neural Network during Seizures

Comput Math Methods Med. 2018 Oct 15:2018:1354915. doi: 10.1155/2018/1354915. eCollection 2018.

Abstract

Epilepsy has been considered as a network-level disorder characterized by recurrent seizures, which result from network reorganization with evolution of synchronization. In this study, the brain networks were established by calculating phase synchronization based on electrocorticogram (ECoG) signals from eleven refractory epilepsy patients. Results showed that there was a significant increase of synchronization prior to seizure termination and no significant difference of the transitions of network states among the preseizure, seizure, and postseizure periods. Those results indicated that synchronization might participate in termination of seizures, and the network states transitions might not dominate the seizure evolution.

MeSH terms

  • Adolescent
  • Adult
  • Brain / physiopathology
  • Child
  • Cortical Synchronization*
  • Drug Resistant Epilepsy / physiopathology
  • Electrocorticography / statistics & numerical data
  • Female
  • Humans
  • Male
  • Mathematical Concepts
  • Models, Neurological
  • Nerve Net / physiopathology*
  • Seizures / physiopathology*