A rare case of primary thyroid amyloidosis

M A Cannizzaro; S Lo Bianco; W Saliba; S D'Errico; F Pennetti Pennella; G Buttafuoco; D Provenzano; G Magro

doi:10.1016/j.ijscr.2018.10.033

A rare case of primary thyroid amyloidosis

Int J Surg Case Rep. 2018:53:179-181. doi: 10.1016/j.ijscr.2018.10.033. Epub 2018 Oct 25.

Authors

M A Cannizzaro¹, S Lo Bianco², W Saliba³, S D'Errico², F Pennetti Pennella², G Buttafuoco³, D Provenzano², G Magro³

Affiliations

¹ Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Catania, Italy. Electronic address: cannizza@unict.it.
² Resident in General Surgery Training Program, Department General surgery and medical-surgical specialties, Endocrinesurgery Unit, "Policlinico-Vittorio Emanuele" Hospital, Catania, Italy.
³ Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Catania, Italy.

Abstract

Introduction: Amyloid goiter is due to the deposition of amyloid in the thyroid, resulting with enlargement of the gland and compressive symptoms.

Case: We herein present a case of a 45-year-old male patient who complained of a big swelling in the neck. Ultrasound showed an enlarged thyroid gland with mediastinal involvement. The multinodular appearance was consistent with the diagnosis of multinodular goiter. He had a history of multiple myeloma but no sign of systemic amyloidosis.

Discussion: Thyroid gland was removed and the histopathological examination revealed a diffuse deposition of amyloid associated with metaplastic lipomatosis of the stroma.

Conclusions: The treatment of choice in patients with amyloid goiter is total thyroidectomy to solve compression symptoms.

Keywords: Amyloidosis; Goiter; Primary amyloidosis; Thyroid; Thyroid disease.