Nodal-ring materials with a spin-polarized feature have attracted intensive interest recently due to their exotic properties and potential applications in spintronics. However, such a type of two-dimensional (2D) lattice is rather rare and difficult to realize experimentally. Here, we identify the first 2D Honeycomb-Kagome (HK) lattice, Mn-Cyanogen, as a new single-spin nodal-ring material by using first-principles calculations. Mn-Cyanogen shows gapless and semiconducting properties in spin-up and spin-down orientations, respectively, indicating a spin-gapless semiconductor nature. Remarkably, a spin-polarized nodal ring induced by px,y/pz band inversion is captured from the 3D band structure, which is irrelevant to spin-orbit coupling. The origin of the single-spin nodal-ring can be further clarified by the effective tight-binding (TB) model. These results open a new avenue to achieving spin-polarized nodal-ring materials with promising applications in spintronic devices.