Understanding and repurposing CRISPR-mediated alternative splicing

Genome Biol. 2018 Nov 6;19(1):184. doi: 10.1186/s13059-018-1565-3.

Jordan L Smith¹, Haiwei Mou¹, Wen Xue^{2

3}

¹ RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
² RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, 01605, USA. Wen.Xue@umassmed.edu.
³ Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, and Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Plantation Street, Worcester, MA, 01605, USA. Wen.Xue@umassmed.edu.

Abstract

Two new studies refine our understanding of CRISPR-associated exon skipping and redefine its utility in engineering alternative splicing.