Objective:To explore the relationship between the levels of serum nerve growth factor(NGF), hemeoxygenase 1(HO-1),interleukin-1 beta (IL-1β) and cognitive function in OSAHS patients. Method:the levels of serum NGF, HO-1 and IL-1β concentrations in 60 severe OSAHS patients were measured before and after treatment, and the Montreal cognitive score (MoCA), AHI and the LSaO₂ were also recorded. Result:①OSAHS patients have serum NGF decreased and serum HO-1, IL-1β increased.②In severe OSAHS patients the AHI was negatively correlated with NGF (r=－0.648), positively correlated with HO-1 (r=0.695), and positively correlated with IL-1β(r=0.616).③The MoCA value was positively correlated with NGF (r=0.663), negatively correlated with HO-1 (r=－0.614), and negatively correlated with IL-1β(r=－0.346).④After half a year of follow-up, the AHI and Serum HO-1 and IL-1β were significantly decreased, while the MoCA values and serum NGF were significantly increased after treatment. Conclusion:①Severe OSAHS patients have cognitive impairment.②The changes of serum NGF, HO-1 and IL-1β may be related to the changes of cognitive function in OSAHS patients. ③Comprehensive treatment can improve the patient's LSaO₂,reduce AHI, and improve the cognitive function.④Regular monitoring the concentration of serum NGF, HO-1, and IL-1β may be helpful to assess the patient's condition and recovery.
Keywords: cognition function; hemeoxygenase 1; interleukin-1 beta; nerve growth factor; sleep apnea hypopnea syndrome, obstructive.
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