Correlation of IL28B rs12979860 genotype and gender with spontaneous clearance of HCV infection: a Pakistani cross-section study

Per Med. 2018 Nov;15(6):495-502. doi: 10.2217/pme-2018-0016. Epub 2018 Nov 6.

Abstract

Aim: There is a strong correlation of IL28B rs12979860 genetic variations and gender with spontaneous clearance of hepatitis C virus (HCV) infection.

Materials & methods: HCV-infected subjects were categorized into HCV spontaneous clearance (SC) group and chronic hepatitis C (CHC) group on the basis of anti-HCV antibodies and HCV RNA level and follow-up of 6 months. 35 subjects were classified in SC group and 165 subjects were classified in CHC group. IL28B rs12979860 genotypes were determined by allele-specific PCR.

Results & conclusion: Multinominal logistic regression analyses revealed that both genders favor IL28B rs12979860 CT genotype (OR: 4.80; CI: 2.22-10.35; p = 0.0005) and (OR: 3.47; CI: 1.63-7.43; p = 0.001) for male and female, respectively, are significant in spontaneous clearance of HCV infection.

Keywords: IL28B; PCR; anti-HCV antibody; genotypes; hepatitis C virus; host; infection; response; spontaneous clearance; treatment.

MeSH terms

  • Adult
  • Alleles
  • Cross-Sectional Studies
  • Female
  • Genetic Association Studies
  • Genotype
  • Hepacivirus / pathogenicity
  • Hepatitis C / genetics
  • Hepatitis C / metabolism
  • Hepatitis C Antibodies
  • Hepatitis C, Chronic / genetics*
  • Hepatitis C, Chronic / metabolism
  • Humans
  • Interferons
  • Interleukins / genetics*
  • Interleukins / metabolism
  • Male
  • Middle Aged
  • Pakistan / epidemiology
  • Polymorphism, Single Nucleotide / genetics
  • Sex Factors
  • Viral Load / genetics*

Substances

  • Hepatitis C Antibodies
  • interferon-lambda, human
  • Interleukins
  • Interferons