A new oleanane triterpene from the leaves of Ficus hirta

Dao Duc Thien; Tran Duc Dai; Nguyen Hoang Sa; NguyenThi Lieu; Trinh Thi Thuy; Nguyen Thi Hoang Anh; Tran Duc Quan; Le Quoc Thang; Domenico V Delfino; Nguyen Thanh Tam

doi:10.1080/14786419.2018.1517122

A new oleanane triterpene from the leaves of Ficus hirta

Nat Prod Res. 2019 Nov;33(21):3065-3069. doi: 10.1080/14786419.2018.1517122. Epub 2018 Nov 6.

Authors

Dao Duc Thien¹, Tran Duc Dai^{2

3}, Nguyen Hoang Sa⁴, NguyenThi Lieu⁵, Trinh Thi Thuy^{1

2}, Nguyen Thi Hoang Anh^{1

2}, Tran Duc Quan¹, Le Quoc Thang⁶, Domenico V Delfino⁷, Nguyen Thanh Tam^{1

2}

Affiliations

¹ Natural Products Research Laboratory, Institute of Chemistry, Vietnam Academy of Science and Technology , Cau Giay , Ha Noi , Vietnam.
² Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology Cau Giay , Ha Noi , Vietnam.
³ Department Medicine and Pharmacy, Tan Trao University , Yen Son District , Tuyen Quang , Vietnam.
⁴ Department of Chemistry, University of Khanh Hoa , Nha Trang , Khanh Hoa , Vietnam.
⁵ Natural Science Department, Hanoi Petropolitan University , Cau Giay , Ha Noi , Vietnam.
⁶ Department of Chemistry, Hue University's College Education , Hue , Vietnam.
⁷ Section of Pharmacology, Department of Medicine, University of Perugia Perugia , Italy.

PMID: 30398364
DOI: 10.1080/14786419.2018.1517122

Abstract

Repeated column chromatography of the n-hexane extract of Ficus hirta leaves (Moraceae) led to isolation of a new oleanane triterpene, 3β-hydroxy-11-oxo-olean-12-enyl-3-stearate (1) in addition to three known compounds, taraxerol (2), 3β-acetoxy-11α-methoxy-12-ursene (3) and 3β-acetoxy-11α-hydroxy-12-ursene (4). Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literatures.

Keywords: 3β-hydroxy-11-oxo-olean-12-enyl-3-stearate; Ficus hirta; Moraceae; leaves; triterpene.

MeSH terms

Ficus / chemistry*
Molecular Structure
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Plant Extracts / chemistry
Plant Leaves / chemistry
Spectrum Analysis
Triterpenes / isolation & purification*

Substances

Plant Extracts
Triterpenes
oleanane
Oleanolic Acid
taraxerol