Two new sesquiterpenoids from the marine-sediment-derived fungus Trichoderma harzianum P1-4

Nat Prod Res. 2019 Nov;33(21):3127-3133. doi: 10.1080/14786419.2018.1522314. Epub 2018 Nov 6.

Abstract

Three cyclonerane sesquiterpenoids, including the known cyclonerodiol (1), together with its new derivatives, (10E)-12-acetoxy-10-cycloneren-3,7 -diol (2) and 12-acetoxycycloneran-3,7-diol (3) were isolated from the cultures of marine-sediment-derived fungus Trichoderma harzianum P1-4. The structures of the new compounds (2 and 3) were elucidated based on extensive spectroscopic methods (1D/2D NMR and HR-MS) and optical rotation analysis.

Keywords: Trichoderma harzianum; cyclonerodiol; marine fungus; sesquiterpenoid.

Publication types

  • Video-Audio Media

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Drug Evaluation, Preclinical
  • Geologic Sediments / microbiology
  • Magnetic Resonance Spectroscopy / methods
  • Molecular Structure
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Staphylococcus aureus / drug effects
  • Trichoderma / chemistry*

Substances

  • Anti-Bacterial Agents
  • Sesquiterpenes
  • cyclonerodiol