Synthesis of Proteins Encoded by the Early Genes E2, E6, and E7 of Papillomavirus of Type 16 in the Plant Expression System

Dokl Biochem Biophys. 2018 Sep;482(1):271-274. doi: 10.1134/S1607672918050113. Epub 2018 Nov 5.

Abstract

An expression system for the synthesis of early antigenic proteins HPV16 E2, HPV16 E6, and HPV16 E7 of high-risk papillomavirus based on transgenic tomato fruits was developed. It is planned to use the early antigenic proteins synthesized to create a therapeutic vaccine against cervical cancer.

MeSH terms

  • Antigens / chemistry
  • Antigens / genetics
  • Blotting, Western
  • DNA-Binding Proteins / genetics*
  • Enzyme-Linked Immunosorbent Assay
  • Escherichia coli / genetics
  • Oncogene Proteins, Viral / genetics*
  • Papillomavirus E7 Proteins / genetics*
  • Plant Proteins / metabolism*
  • Plants, Genetically Modified / genetics
  • Plants, Genetically Modified / metabolism
  • Repressor Proteins / genetics*
  • Solanum lycopersicum
  • Transcriptome

Substances

  • Antigens
  • DNA-Binding Proteins
  • E2 protein, Human papillomavirus type 16
  • E6 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Plant Proteins
  • Repressor Proteins
  • oncogene protein E7, Human papillomavirus type 16