Clinicians will have to face an increasing numbers of older HIV-infected patients in coming years. The age cut-off of 50 years often adopted to define "elderly" patients with HIV/AIDS is younger than that usually used in most other settings. The present contribution discusses the main peculiarities and new outcomes of interest of this class of patient from the clinical psychology perspective; the contribution is divided in three section exploring cognitive disorders, psycho-emotional problems and health-related quality of life proposing both a brief synthesis of the main evidence from the literature and some insights and proposals for the importance of involving a psychologist in the clinical care of these patients.