Stem Cell-Mediated Angiogenesis in Tissue Engineering Constructs

Curr Stem Cell Res Ther. 2019;14(3):249-258. doi: 10.2174/1574888X13666181105145144.

Abstract

Angiogenesis has always been a concern in the field of tissue engineering. Poor vascularization of engineered constructs is a problem for the clinical success of these structures. Among the various methods employed to induce angiogenesis, stem cells provide a promising tool for the future. The present review aims to present the application of stem cells in the induction of angiogenesis. Additionally, it summarizes recent advancements in stem cell-mediated angiogenesis of different tissue engineering constructs.

Keywords: Angiogenesis; hypoxia; in-situ; in-vitro; stem cell; tissue engineering..

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chemokine CXCL12 / genetics
  • Chemokine CXCL12 / metabolism
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / physiology
  • Endothelial Cells / cytology*
  • Endothelial Cells / physiology
  • Gene Expression Regulation
  • Glial Cell Line-Derived Neurotrophic Factor / genetics
  • Glial Cell Line-Derived Neurotrophic Factor / metabolism
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Neovascularization, Pathologic / genetics*
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / pathology
  • Neovascularization, Physiologic*
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / physiology
  • Signal Transduction
  • Stem Cell Transplantation
  • Tissue Engineering / methods*
  • Tissue Scaffolds
  • Vascular Endothelial Growth Factor A / genetics*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • CXCL12 protein, human
  • Chemokine CXCL12
  • Glial Cell Line-Derived Neurotrophic Factor
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A