Abstract
Angiogenesis has always been a concern in the field of tissue engineering. Poor vascularization of engineered constructs is a problem for the clinical success of these structures. Among the various methods employed to induce angiogenesis, stem cells provide a promising tool for the future. The present review aims to present the application of stem cells in the induction of angiogenesis. Additionally, it summarizes recent advancements in stem cell-mediated angiogenesis of different tissue engineering constructs.
Keywords:
Angiogenesis; hypoxia; in-situ; in-vitro; stem cell; tissue engineering..
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MeSH terms
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Animals
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Cell Differentiation
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Chemokine CXCL12 / genetics
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Chemokine CXCL12 / metabolism
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / physiology
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Endothelial Cells / cytology*
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Endothelial Cells / physiology
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Gene Expression Regulation
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Glial Cell Line-Derived Neurotrophic Factor / genetics
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Glial Cell Line-Derived Neurotrophic Factor / metabolism
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Humans
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Mesenchymal Stem Cells / cytology*
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Mesenchymal Stem Cells / physiology
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Neovascularization, Pathologic / genetics*
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Neovascularization, Pathologic / metabolism
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Neovascularization, Pathologic / pathology
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Neovascularization, Physiologic*
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Pluripotent Stem Cells / cytology
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Pluripotent Stem Cells / physiology
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Signal Transduction
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Stem Cell Transplantation
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Tissue Engineering / methods*
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Tissue Scaffolds
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Vascular Endothelial Growth Factor A / genetics*
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Vascular Endothelial Growth Factor A / metabolism
Substances
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CXCL12 protein, human
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Chemokine CXCL12
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Glial Cell Line-Derived Neurotrophic Factor
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VEGFA protein, human
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Vascular Endothelial Growth Factor A