Protective effect of Epicatechin on APAP-induced acute liver injury of mice through anti-inflammation and apoptosis inhibition

Nat Prod Res. 2020 Mar;34(6):855-858. doi: 10.1080/14786419.2018.1503261. Epub 2018 Nov 3.

Abstract

Epicatechin (EC) is the most effective compound in Euonymus alatus (Thunb.)Sieb, and possesses a series of benefits, including anti-inflammatory, antioxidant, antiobesity and anticancer effects. In this study, we investigated the protective effects of EC in Acetaminophen(N-acetyl-p-aminophenol, APAP)-induced acute liver injury in C57BL/6J mice and explored the possible mechanisms involved in these effects.[Formula: see text].

Keywords: APAP; EC; acute liver injury; anti-inflammation; apoptosis.

MeSH terms

  • Acetaminophen / adverse effects
  • Animals
  • Antioxidants / pharmacology
  • Apoptosis / drug effects*
  • Catechin / pharmacology
  • Catechin / therapeutic use*
  • Chemical and Drug Induced Liver Injury / drug therapy*
  • Inflammation / metabolism
  • Inflammation / prevention & control*
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress / drug effects
  • Protective Agents / pharmacology
  • Protective Agents / therapeutic use

Substances

  • Antioxidants
  • Protective Agents
  • Acetaminophen
  • Catechin