Natural Products from Mammalian Gut Microbiota

Leli Wang; Vinothkannan Ravichandran; Yulong Yin; Jia Yin; Youming Zhang

doi:10.1016/j.tibtech.2018.10.003

Natural Products from Mammalian Gut Microbiota

Trends Biotechnol. 2019 May;37(5):492-504. doi: 10.1016/j.tibtech.2018.10.003. Epub 2018 Nov 2.

Authors

Leli Wang¹, Vinothkannan Ravichandran², Yulong Yin³, Jia Yin⁴, Youming Zhang⁵

Affiliations

¹ Laboratory of Animal Nutrition and Human Health, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, College of Life Science, Hunan Normal University, 410081, Changsha, China; These authors contributed equally to this work.
² Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Suzhou Institute of Shandong University, 266235, Qingdao, China; These authors contributed equally to this work.
³ Laboratory of Animal Nutrition and Human Health, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, College of Life Science, Hunan Normal University, 410081, Changsha, China; Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, 410125, Changsha, China.
⁴ Laboratory of Animal Nutrition and Human Health, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, College of Life Science, Hunan Normal University, 410081, Changsha, China; Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Suzhou Institute of Shandong University, 266235, Qingdao, China. Electronic address: jiayin@hunnu.edu.cn.
⁵ Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Suzhou Institute of Shandong University, 266235, Qingdao, China. Electronic address: zhangyouming@sdu.edu.cn.

PMID: 30392727
DOI: 10.1016/j.tibtech.2018.10.003

Abstract

The mammalian gut has a remarkable abundance of microbes. These microbes have strong potential to biosynthesize distinct metabolites that are promising drugs, and many more bioactive compounds have yet to be explored as potential drug candidates. These small bioactive molecules often mediate important host-microbe and microbe-microbe interactions. In this review, we provide perspectives on and challenges associated with three mining strategies - culture-based, (meta)genomics-based, and metabolomics-based mining approaches - for discovering natural products derived from biosynthetic gene clusters (BGCs) in mammalian gut microbiota. In addition, we comprehensively summarize the structures, biological functions, and BGCs of these compounds. Improving these techniques, including by using combinatorial approaches, may accelerate drug discovery from gut microbes.

Keywords: biosynthetic gene clusters; culture-based mining approaches; genome metagenomics; gut microbiota; metabolomics; natural products.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacteria* / chemistry
Bacteria* / genetics
Bacteria* / metabolism
Biological Products*
Drug Discovery
Gastrointestinal Microbiome*
Genomics
Humans
Mammals / microbiology*

Substances

Biological Products