Pancreatic cancer is a fatal disease with low resectability, high recurrence rate and despairing prognosis.Neoadjuvant therapy has been proven to improve resectability, especially R0 resection rate, and extend overall survival.It has become the hotspot in the field of pancreatic cancer in the last decade.However, the concomitant adverse effects on surgery and postoperative complication also draw wide attention.In this reivew, the indication and the effects of neoadjuvant therapy on pancreas and body composition according the latest studies are summarized.Futhermore, the effects of neoadjuvant therapy on postoperative complication from multiple aspects are discussed.
胰腺癌恶性程度高，手术切除率低，术后复发率高，预后极差。新辅助治疗可提高手术切除率与R0切除率，延长患者整体生存期，成为近年来胰腺癌领域的研究热点。但新辅助治疗是否会影响手术及术后并发症也同样成为关注点。本文回顾了胰腺癌新辅助治疗的最新研究结果，总结新辅助治疗的适用范围、对胰腺及机体组成的影响，并结合作者的临床经验，深入探讨了新辅助治疗对胰腺癌术后并发症的影响。.
Keywords: Neoadjuvant therapy; Pancreatic neoplasms; Postoperative complications.